The US-4x4HR is equipped with 4 mic/line inputs with guitar input support on IN 1-2 plus 2 headphone outputs that can be put to use in various music/multi-media production environments such as vocal/guitar simultaneous recordings and multitrack recordings. The unit is also equipped with a USB-C port to be easily powered by USB bus power.

High resolution reproduction in the US-HR series has been pursued based on TASCAM's policy to recreate sound as close to the original as possible. Therefore, the in-house developed Ultra HDDA mic preamp combined with a newly improved audio circuit delivers enhanced audio performance with the most transparent and low-noise sound.

Direct monitoring will diverge signals before sending them to the computer, resulting in smooth, in-time monitoring without any sound delay during both recording and performance.

US-HR models also come with a free 3-month subscription to Auto-Tune Unlimited, a comprehensive suite of industry standard pitch correction and vocal effects.

The US-4x4HR can be used with computers or smartphones to easily create podcasts or live streams. The audio can be switched between stereo/mono, and the loopback function allows the audio from the computer to be returned to the streaming software for playback during live streams. US-4x4HR also supports OBS, which is popular and used worldwide.